PQQ (pyrroloquinoline quinone) is a redox cofactor that is found in certain foods, such as fermented soybeans, parsley, green peppers, kiwi fruit, and papaya. It is also synthesized by certain bacteria, and plays a role in energy metabolism and oxidative stress. Over the past decade, researchers have become interested in the potential health benefits of PQQ, particularly its potential role in promoting longevity.

One of the key ways in which PQQ may promote longevity is by supporting mitochondrial function. Mitochondria are organelles within cells that are responsible for generating energy, and they are also involved in cellular signaling, differentiation, and apoptosis (death of cells). However, mitochondrial function can become impaired with age, leading to decreased energy production, increased oxidative stress, and other cellular damage. Studies have shown that PQQ can help to protect and support mitochondrial function by increasing mitochondrial biogenesis, reducing oxidative stress, and enhancing cellular respiration.

For example, in a study published in the Journal of Nutrition in 2010, researchers investigated the effects of PQQ supplementation on mitochondrial function in rats. They found that rats that were given PQQ had significantly higher levels of mitochondrial biogenesis, as well as increased activity of key mitochondrial enzymes. Additionally, PQQ supplementation was associated with a decrease in markers of oxidative stress, suggesting that PQQ may help to protect mitochondria from damage.

Another way in which PQQ may promote longevity is by reducing inflammation. Chronic inflammation is a hallmark of aging and is linked to a variety of age-related diseases, including cardiovascular disease, diabetes, and Alzheimer’s disease. PQQ has been shown to have anti-inflammatory effects in a number of studies, which may help to protect against age-related inflammation and its associated health risks.

In a study published in the Journal of Nutritional Biochemistry in 2013, researchers investigated the effects of PQQ on inflammation and oxidative stress in a mouse model of Alzheimer’s disease. They found that mice that were given PQQ had lower levels of pro-inflammatory cytokines, as well as decreased oxidative stress in the brain. Additionally, PQQ supplementation was associated with improved cognitive function in the mice, suggesting that PQQ may have potential as a treatment for Alzheimer’s disease.

PQQ may also promote longevity by enhancing neuroprotection. The brain is particularly vulnerable to oxidative stress and damage, which can lead to cognitive decline and neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Studies have shown that PQQ may help to protect the brain from oxidative stress and damage, and may even promote the growth and survival of neurons.

For example, in a study published in the Journal of Neurochemistry in 2011, researchers investigated the effects of PQQ on neuronal survival in a rat model of Parkinson’s disease. They found that rats that were given PQQ had higher levels of neuronal survival in the substantia nigra, a region of the brain that is particularly affected by Parkinson’s disease. Additionally, PQQ supplementation was associated with improved motor function in the rats, suggesting that PQQ may have potential as a treatment for Parkinson’s disease.

Finally, PQQ may promote longevity by enhancing energy metabolism. As we age, our metabolism slows down, and we may become more prone to fatigue and decreased energy levels. PQQ has been shown to enhance cellular respiration, which may help to improve energy levels and reduce fatigue.

In a study published in the Journal of Clinical Biochemistry and Nutrition in 2013, researchers investigated the effects of PQQ on energy metabolism in humans. They found that healthy adults who were given PQQ had significantly higher levels of mitochondrial function and cellular respiration, as well as improved markers of oxidative stress.

The evidence suggests that PQQ may have potential as a longevity treatment, so maybe try to add a little more fermented soybeans in your diet.